Photo-crosslinkable polymer platform to serve medical applications

presentation by Sandra Van Vlierberghe, Ghent University.

Biofabrication is a specific area within the field of tissue engineering which takes advantage of rapid manufacturing (RM) techniques to generate 3D structures which mimic the natural extracellular matrix (ECM). A popular material in this respect is gelatin, as it is a cost-effective collagen derivative, which is the major constituent of the natural ECM.

The material is characterized by an upper critical solution temperature making the material soluble at physiological conditions. To tackle this problem, the present work focusses on different gelatin functionalization strategies which enable covalent stabilization of 3D gelatin structures [1, 2].

In a second part, synthetic acrylate-endcapped, urethane-based precursors (AUP) based on polyethers and polyesters, will be discussed with exceptional crosslinking behaviour and CAD-CAM mimicry compared to conventional materials [3]. Within this synthetic material class, also insight will be provided on the shape memory properties of polyester-based AUPs (two filed patents). Both chain growth and step growth polymerization mechanisms (see figure) along with their mechanical properties and processability potential will also be addressed.

Several polymer processing techniques will be covered including conventional 3D printing using the Bioscaffolder 3.1 and two-photon polymerization [4, 5]. A number of biomedical applications will be tackled including adipose tissue engineering [6, 7], vascularization [8], ocular applications [9], etc. In a final part, attention will be paid to the valorization of our biomaterial platform technology through the launch of our spin-off company Xpect-INX. The results show that chemistry is a valuable tool to tailor the properties of (bio)polymers towards processing while preserving the material biocompatibility.

  1. J. Van Hoorick et al., Macromolecular Rapid Communications, 2018, 39, 1800181.
  2. J. Van Hoorick et al., Biomacromolecules 2017, 18, 3260-3272.
  3. A. Houben et al., WO 2017/005613.
  4. J. Van Hoorick et al., Biofabrication, 2020, accepted.
  5. A. Arslan et al., Materials Today, 2020, accepted.
  6. L. Tytgat et al., Acta Biomaterialia, 2019, accepted.
  7. L. Van Damme et al., Biomaterials Science, 2020, submitted.
  8. L. Tytgat et al., Macromolecular Bioscience 2020 accepted.
  9. J. Van Hoorick et al., Advanced Healthcare Materials 2020 accepted.

Sandra van Vlierberghe will speak at the 2021 conference edition.

3D Medtech Conference organised by Jakajima focuses on applications of 3D printing in Health Care: medical implants, surgical guides, surgical instruments, medical devices and hearing aids. The conference will showcase the work of researchers and industry in the 3D Medtech Printing field and its applications, with a view to fostering closer ties and collaborations. The overall goal of this conference is to address both the technologies and the applications — from early technology development to downstream applications.

  • The conference is accredited by The Dutch Association for Technical Medicine with 4 (Continuing Medical Education) CME credits.
  • It is part of the 3D Medical Printing Series, which includes other related conferences: 3D Pharmaceutical Printing Conference, 3D Bioprinting Printing Conference and 3D Dental Printing Conference. We recommend you to take a look at the program of the other conferences as well, since there are also cross-disciplinary themes and topics – Combi tickets are also available if you are interested in attending in the other conferences as well. They are all accredited with 4 CME credits each.
  • During the roundtable discussion interaction between attendees and speakers will also be possible.

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